Updating risk prediction tools a case study in prostate cancer dating and conflict resolution


20-Jun-2019 11:19

updating risk prediction tools a case study in prostate cancer-60

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Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors.Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide,1 accounting for approximately one third of all deaths.2 Prevention of CVD requires timely identification of people at increased risk to target effective dietary, lifestyle, or drug interventions.The list of extracted items was based on the recently issued Cochrane guidance for data extraction and critical appraisal for systematic reviews of prediction models (the CHARMS checklist15) supplemented by items obtained from methodological guidance papers and previous systematic reviews in the specialty.15 28 29 30 31 The full list of extracted items is available on request.

Some of these prediction models are included in clinical guidelines for therapeutic management10 11 and are increasingly advocated by health policymakers.

Additionally, two presented models yielding the same predictor-outcome associations but with a different baseline hazard or risk estimate, were considered separately.



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